Best response and survival data. (A) Best hematologic response. Among the ITT population (n = 22), 9 patients had VGPR, and 3 had PR. Of the 14 patients treated at RP2D (DL3), the overall hematologic response rate (CR/VGPR/PR) was 64%, with 8 achieving VGPR and 1 PR. (B) OS by best hematologic response. All patients achieving hematologic response (≥PR) are alive, and there was a statically significant difference between the groups (P = .011). DL3, dose level 3; IIT, intention to treat; NE, not evaluable; NR, no response; PR, partial response; VGPR, very good partial response.