The association between genotype and desmopressin response is mediated via the pathophysiological defects of VWF. Each point represents 1 patient. Dashed lines represent the cut-off values for reduced synthesis/secretion and increase clearance of VWF. (A) Type 1 VWD. Triangles represent patients with a VWF gene variant, whereas dots represent patients without a VWF gene variant. (B) Type 2 VWD. Dots represent patients with type 2A, squares represent patients with type 2M and triangles represent patients with type 2N VWD.