Type 2 VWD patients with the same VWF gene variants have comparable responses to desmopressin. Each line represents a single patient. (A) Type 2A VWD. ¹One patient also had G1609R. (B) Type 2M VWD. ²One patient also had R1374H. (C) VWF:Act in patients with type 2N VWD. VWF:Act was in most type 2N patients recorded as ≥1.00 IU/mL in the electronic patient files, in case of high levels, explaining the straight line from 1 to 4 hours in panel C. (D) FVIII:C in patients with type 2N VWD. ³Homozygous variant.