Response to treatment with combination copanlisib/ibrutinib. (A) Waterfall plot of best responses demonstrating 87.5% response rate. Percent change in index lesions is reflected in the y-axis, while categorical response by RECIL criteria, which incorporates both size and FDG avidity, is reflected by color index. Patient 2 had CR by RECIL criteria based on a decrease in the sum of the longest diameters of index lesions of at least 30%, plus normalization of FDG-PET avidity. (B) Swimmer plot of all 8 treated patients.