Decreased infiltration of CD3⁺, CD4⁺, and granzyme-B⁺ tumor-infiltrating lymphocytes (TILs) in SOX11⁺ compared with SOX11⁻ nodal MCL primary cases. (A) Representative histological sections from SOX11⁺ and SOX11⁻ nodal MCLs stained with specific anti-human CD20, cyclin D1, SOX11, CD3, CD4, CD8, and granzyme B (GZMB) antibodies (×40). Pictures contain insets with magnification (×200). (B) IHC quantifications of CD3⁺, CD4⁺, CD8⁺, and GZMB⁺ TILs and CD4⁺/CD8⁺ T-cell ratio in SOX11⁺ and SOX11⁻ nodal MCLs. The significance of difference was determined by independent-samples Student t test: *P < .05, **P < .01. HPF, number of cells per high-power field (×400).