Pathway topology and functional interaction networks in ET and RT. (A-B) Venn diagram delineating pathway overrepresentation analysis using significantly associated (P < .05) ET and RT gene/SNVs (A) and top 10 pathways each for common, ET-, or RT-restricted phenotypes (B). Scale bar (adjusted.P) is shown. (C-D) Functional interaction networks in ET and RT were generated by applying global adaptive rank truncated product method to the SNV association data.³⁷  For the nodes, genes are represented by round symbols, and node color reflects the adjusted P value²⁸  on a continuous scale from low (light green) to high (dark blue). Gray-colored round symbols identify first-order interactors, and core genes not connected to the main network are omitted. The ET network includes 12 core genes (encompassing 127 nodes and 362 edges), and the RT network includes 26 core genes (encompassing 150 nodes and 633 edges). Scale bar [(−log₁₀(adjusted.P)] is shown. FGFR, fibroblast growth factor receptor; PDGF, platelet-derived growth factor.