Figure 1.
![Genotyping overview. (A) Work-flow schema showing clinical characteristics and genotyping strategy. (B) Genetic overrepresentative analysis (N = 311 genes) was completed by using Reactome,36 and enriched pathways are highlighted in yellow. (C-E) Genome-wide association plots (aggregate ET and RT [C], ET [D], and RT [E]) detailing significant gene/SNVs (at P < .01) identified by dominant, allelic, or recessive models; the most significant gene/SNVs (P < .001) are in red (Table 1). HWE, Hardy-Weinberg equilibrium; NA, not available.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/6/16/10.1182_bloodadvances.2021005648/1/advancesadv2021005648f1.png?Expires=1724962842&Signature=N9OfGAyv2AwdPnebOJICD93-KUaN1WiQpg4lj~2wh5278W3Tm0kVxWjDkC6Hvm~-4jaetoH3GdzPw93~KcIu7soOcwAJ6HZthBS8IKYki9TqNuxPbTcdX469q7doPimPXME08eVgIplG~oEoRC7DOFpg0HZGcqQmSPVUgbnepYbRoCqKIw8G19602ieyzhYu17WDMItyJUj5ShRHQJXjLzE-3t9mbWgAa3wmh7XLNHTvk~xBhRXYYlnRBYXdpsW-p6KTC6CLAzVeTohrwtcj-UgmNMBC6vJGRbxT1ScAv2Zmvw0UAgubzRLP4~pu6nGnPNY3lxSrZr9sAIRwDDW1xg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genotyping overview. (A) Work-flow schema showing clinical characteristics and genotyping strategy. (B) Genetic overrepresentative analysis (N = 311 genes) was completed by using Reactome,36 and enriched pathways are highlighted in yellow. (C-E) Genome-wide association plots (aggregate ET and RT [C], ET [D], and RT [E]) detailing significant gene/SNVs (at P < .01) identified by dominant, allelic, or recessive models; the most significant gene/SNVs (P < .001) are in red (Table 1). HWE, Hardy-Weinberg equilibrium; NA, not available.