The kinase profile was constructed through KinMap, a web-based interactive tool with built-in human kinome data.⁴¹  Kinome profile of PAC adapted from Singer et al¹⁶  and the kinase profiles of ruxolitinib and fedratinib from Mullally et al.⁴²  The numbers represent the half maximal inhibitory concentration (IC₅₀) of the respective kinases on the far-left corner. AGC, protein kinase A; G, C group; CAMK, calcium/calmodulin-dependent protein kinases; CK1, casein kinase; CMGC, includes cyclin-dependent kinases (CDKs), mitogen-activated protein kinases (MAP kinases), glycogen synthase kinases (GSK) and CDK-like kinases; FLT3, fms-like receptor tyrosine kinase 3; IRAK1, interleukin-1 receptor-associated kinase 1; STE, homolog of sterile; TK, tyrosine kinase; TKL, tyrosine kinase-like group of kinases, TYK2-tyrosine kinase 2.