Outcome of patients with DDX41^MutGL compared with DDX41^WT AML. (A) CR/CRp rates after one induction course in DDX41^MutGL compared with DDX41^WT AML patients stratified according to the ELN-2017 classification. P values from the bivariate regression for response are reported. Error bars represent the 95% CIs calculated according to the exact method. OS (B) and RFS (C) censored at HSCT in CR1 in patients with DDX41^MutGL (red) vs DDX41^WT ELN-2017 favorable (blue) and DDX41^WT ELN-2017 Int/Adv (green). Results of the RMST analyses at 5 years (OS-HSCT) and at 3 years (RFS-HSCT) are reported. (D) Cumulative incidence of relapse (top) and death (bottom) censored at HSCT in CR1 in DDX41^MutGL and DDX41^WT AML. (E) Simon-Makuch plot of OS according to achievement of HSCT in first CR in DDX41^MutGL patients (top) and ELN-2017 Int/Adv DDX41^WT patients (bottom). Results of the bivariate time-dependent Cox models are reported. (F) Cumulative incidence of relapse (top) and nonrelapse death (bottom) after HSCT in first CR.