Comparison of alteration frequencies of PNMZL versus adult NMZL and PTFL. (A) Comparison of mutation frequency of genes recurrently mutated in PNMZL and in adult NMZL.^5,6  For statistical comparison, only frequently mutated genes (>5%) and regions analyzed in both groups were considered; that is, all coding sequence of TNFRSF14, KMT2D, TBL1XR1, TNFAIP3, and HIST1H1E and mutation hot spots of MAP2K1, EZH2, FOXO1, TET2, BRAF, KLF2, NOTCH2, PTPRD, and CREBBP. Genes are represented along the horizontal axis, and the mutation frequency is represented on the vertical axis. Adult NMZL is depicted in green, and PNMZL is depicted in purple. Asterisks mark statistically significant differences in the incidence of mutation (Fisher’s exact test, *adjusted P < .05). (B) Comparison of alteration frequency of genes recurrently mutated in PNMZL, cases with overlapping features and PTFL.⁸  Genes are represented along the horizontal axis, and the alteration frequency is represented on the vertical axis. PNMZL is depicted in purple, cases with overlapping features are represented in gray, and PTFL is depicted in blue. Asterisks mark statistically significant differences in the incidence of alteration, with colors indicating the group in which the frequency is significantly different (Fisher’s exact test, *P < .05, **P < .01).