Global CN and CNN-LOH profiles of 44 PNMZL cases and comparison plots with CN data from adult NMZL and CNN-LOH data from PTFL. (A-B) Global CN alterations and CNN-LOH profiles in 44 PNMZL cases. (C) Comparison of CN alterations between adult NMZL (57 cases) and PNMZL (44 cases). (D) Comparison of CNN-LOH regions between PNMZL (44 cases) and PTFL (42 cases). The horizontal axis indicates chromosomes from 1 to Y and from arm p to q. The vertical axis represents the frequency of the genomic event among the analyzed cases. CN gains are depicted in blue, CN losses in red, and CNN-LOH in yellow (in panel C, upward representing CN gains and downward representing CN losses). CN and CNN-LOH data from PNMZL are depicted in purple, CN data from adult NMZL are depicted in green, and CNN-LOH data from PTFL are depicted in blue. Asterisks mark regions with statistically significant differences among groups after applying Fisher’s exact test adjusted; P value < .05, and considering, minimum, 5 altered cases.