TINF2-DC alleles lead to telomere shortening but not a proliferative disadvantage in donor HSPCs in vivo. (A) A schematic of the in vivo humanized mouse model to study the effect of TINF2-DC variants in donor HSPCs. (B) Telomere length analysis of CFU colonies plotted by genotypes. Mann-Whitney test. ****P < .0001. (C) Percentages of frameshift alleles of bulk hCD34⁺ cells before and after engraftment in NBSGW mice. Error bars indicate data point ranges of 3 biological replicates.