Metabolic pathways upregulated by CD40 or BCR were mirrored by IBR. Volcano plots of significantly increased metabolites in baseline+CD40 vs baseline cells (A) or 3-month IBR treatment+BCR vs baselineUN (B). Statistical analyses were performed with paired Student t test with selective threshold P value < .1 and fold change (FC) > 2 (n = 8). (C) Venn diagram showing the metabolic pathways upregulated by CD40 or BCR stimulation. Pathway analysis was performed from significantly increased metabolites in baseline+CD40 vs baseline or 3-month IBR treatment+BCR vs baseline (n = 8) using MetaboAnalyst software (https://www.metaboanalyst.ca/). (D) Volcano plot of significantly decreased metabolites by 3-month IBR treatmentvs baseline. Statistical analyses were performed with paired Student t test with threshold P value < .1 and FC > 2 (n = 8). Top 15 pathways upregulated by CD40 (E) or BCR (F), which were downregulated by IBR treatment. ETC, electron transport chain.