Metabolomic analysis of IBR-treated patient samples stimulated by CD40 or BCR. Heat map showing the abundance of 79 metabolites in CLL cells from 8 samples from patients with CLL at baseline or after 3-month treatment with IBR, which were restimulated by in vitro CD40/BCR for 24 hours. Metabolomic data were analyzed with Tercen software (https://www.tercen.com/) and are represented by z score followed with h clustering. Metabolic signatures induced by IBR treatment and CD40 and BCR stimulation are highlighted in black, yellow, and green, respectively. UN, unstimulated control.