Clinical impact of recurrent copy number anomalies in r/r LBCL. (A) GISTIC significant peaks extracted combining 49 r/r LBCL and samples from 50 PCAWG newly diagnosed cases; amplification (left) and deletion (right). Each plot shows the focal-level and arm-level output; the green dashed line indicates the q-value threshold (q < 0.1). (B) A heat map showing the monoallelic or biallelic alteration of TP53 and CDKN2A in 49 patients with r/r LBCL. (C) A heat map showing the distribution of the 30 focal peaks extracted by GISTIC across 49 patients with r/r LBCL treated with CAR-19. (D-E) Kaplan-Meier plots showing the impact of TP53 loss (D) and deletion 3p21.31 (RHOA) (E) (n = 47).