Clinical features associated with early progression in LBCL treated with CAR-19. (A) Follow-up and clinical outcome of 47 of 49 patients with LBCL included in the PFS and OS analysis (excluded cases: relapse-only sample with transitory complete remission and early therapy-related death not evaluable for PFS). Red arrows indicate ongoing responses. (B) Kaplan-Meier curve for PFS for all 47 patients. (C-D) Kaplan-Meier curves for PFS comparing female vs male (C), patients more or less than 65 years old (D), and low vs high MTV (E).