Simple risk model incorporating FCS from lpWGS. (A) Sankey plot depicting the distribution of low-risk (green), intermediate-risk (blue), and high-risk (red) patients by the 3 variables of the risk model (FCS, LDH, and EN sites). (B-C) Kaplain-Meier plots of PFS (B) and OS (C) of patients divided into the 3 risk groups. Median PFS was not reached, 6.7 months, and 1.9 months with 1-year progression free survival rates of 73%, 43%, and 4% for low- to high-risk patients, respectively. Median OS was not reached, 20.3 months, and 5.0 months with 1-year overall survival rates of 80%, 70%, and 16% for low- to high-risk patients, respectively.