Association between FCS and markers of increased tumor burden. Bar plots depicting the association between elevated FCS (using cutoff of 88.5, median) with markers of elevated tumor burden including elevated LDH, advanced disease stage, >1 EN site of disease, and bulky disease by radiography (at least 5 cm or greater in diameter). P values depicted are from Fisher’s exact test. High FCS was only statistically associated with higher prevalence of >1 EN sites of disease.