Focal copy number alteration burden score (FCS) and 3-month response rates after CART19. (A) Genome-wide copy number alteration profiles from lpWGS of cfDNA of 4 patients with FCS values from each quartile (A, blue = first quartile, red = second quartile, green = third quartile, purple = fourth quartile). Broad copy number alteration burden scores (BCSs) are also included. (B-C) Box plots comparing distribution of (B) FCS and (C) BCS in patients with complete response (blue) or without complete response (red) at the 3-month post-CART19 evaluation demonstrate that FCS and BCS were significantly higher in patients without 3-month complete response.