Figure 1.
In vivo effect of CIC-39Na in WT and KI-STIM1I115F mice. (A) Study design of in vivo treatments in WT and KI-STIM1I115F mice. (B) Platelet count in the indicated groups. Mann-Whitney U test P value: *0.0334 for each experimental point vs WT vehicle. P value: #0.0154, ##0.016; ###0.0001 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. (C) Circulating number of white blood cells and erythrocytes. (D) Absorbance values relative to blood lost in the indicated groups. Mann-Whitney U test. P value: ^^0.003, ^0.0208 for WT vehicle vs KI-STIM1I115F vehicle and #0.0208 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. (E) Bleeding time in mice treated as indicated. P value: ^0.0208 for WT vehicle vs KI-STIM1I115F vehicle, #0.0304 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. Data reported in panels B-E represent the mean ± SEM of 8 animals for each group from 2 independent experiments.

In vivo effect of CIC-39Na in WT and KI-STIM1I115F mice. (A) Study design of in vivo treatments in WT and KI-STIM1I115F mice. (B) Platelet count in the indicated groups. Mann-Whitney U test P value: *0.0334 for each experimental point vs WT vehicle. P value: #0.0154, ##0.016; ###0.0001 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. (C) Circulating number of white blood cells and erythrocytes. (D) Absorbance values relative to blood lost in the indicated groups. Mann-Whitney U test. P value: ^^0.003, ^0.0208 for WT vehicle vs KI-STIM1I115F vehicle and #0.0208 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. (E) Bleeding time in mice treated as indicated. P value: ^0.0208 for WT vehicle vs KI-STIM1I115F vehicle, #0.0304 for KI-STIM1I115F vehicle vs KI-STIM1I115F CIC-39Na. Data reported in panels B-E represent the mean ± SEM of 8 animals for each group from 2 independent experiments.

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