Effect of Iptacopan on LDH and Hb levels. (A) Change in LDH levels over time for iptacopan 25/100 mg and 50/200 mg cohorts (pharmacodynamic analysis set). (B) Change in Hb levels over time for iptacopan 25/100 mg and 50/200 mg cohorts (pharmacodynamic analysis set). Note: 1 patient in cohort 2 (patient 10) was excluded from the Hb analysis due to a protocol deviation, whereby an RBC transfusion was given between screening and baseline, raising the Hb level to above the protocol-defined upper limit of 105 g/L at baseline. bid, twice daily; BL, baseline; LLN, lower limit of normal.