Figure 6.
The dynamics of the absolute count of the T, B, and NK cells among individual patients after NS7CAR T-cell infusion and allo-HSCT. The absolute numbers of T, B, and NK cells of each patient were measured after NS7CAR T-cell therapy. CAR T and malignant T cells were excluded from T-cell counting. The absolute numbers of T/B/NK cells showed a temporary decline, to varying levels, for each patient during the peak of CAR-T proliferation. T/B/NK cells then recovered to the baseline levels but decreased shortly again after allo-HSCT. The 4 patients (Pt.05, Pt.07, Pt.11, and Pt.15) missed the time window for blood check within the 1 week after transplant to observe the decline in T and NK cells. There was an adequate recovery of normal T and NK cells after allo-HSCT.

The dynamics of the absolute count of the T, B, and NK cells among individual patients after NS7CAR T-cell infusion and allo-HSCT. The absolute numbers of T, B, and NK cells of each patient were measured after NS7CAR T-cell therapy. CAR T and malignant T cells were excluded from T-cell counting. The absolute numbers of T/B/NK cells showed a temporary decline, to varying levels, for each patient during the peak of CAR-T proliferation. T/B/NK cells then recovered to the baseline levels but decreased shortly again after allo-HSCT. The 4 patients (Pt.05, Pt.07, Pt.11, and Pt.15) missed the time window for blood check within the 1 week after transplant to observe the decline in T and NK cells. There was an adequate recovery of normal T and NK cells after allo-HSCT.

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