Figure 7.
Selective inhibitors for Syk or Jak3 do not eliminate LMP1/λ-MYC tumors. Mice harboring tumors were treated with 100 mg/kg/day TAK-659 (Syk inhibitor) daily for 10 days (A) or 25 mg/kg/day PF-06651600 (JAK3 inhibitor) daily for 10 days (B). Percentage masses were calculated for spleen and total lymph nodes. Equivalent-age WT mice were included as no tumor controls. Dot plot graphs represent the mean ± standard deviation. P values were calculated by unpaired t test, **P < .01.

Selective inhibitors for Syk or Jak3 do not eliminate LMP1/λ-MYC tumors. Mice harboring tumors were treated with 100 mg/kg/day TAK-659 (Syk inhibitor) daily for 10 days (A) or 25 mg/kg/day PF-06651600 (JAK3 inhibitor) daily for 10 days (B). Percentage masses were calculated for spleen and total lymph nodes. Equivalent-age WT mice were included as no tumor controls. Dot plot graphs represent the mean ± standard deviation. P values were calculated by unpaired t test, **P < .01.

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