Vascular complications of COVID-19. Due to widespread endothelial dysfunction and thrombosis, COVID-19 has the ability to affect nearly any organ. Pulmonary disease, specifically ARDS, may be driven in large part by vascular dysfunction and microvascular thrombosis. Increased thrombotic events, most notably venous thromboembolism but also myocardial infarction and stroke, have been reported. Vascular dysfunction may contribute neurologic, renal, and dermatologic manifestations of COVID-19, as well as post-COVID sequelae such as multisystem inflammatory syndrome in children (MIS-C).