Forest plot of ABO blood group associations with positive functional assay status in discovery and replication cohorts combined. ORs, 95% CIs, and P values were generated using logistic regression adjusted for age, sex, principal components 1-3, and cohort (discovery vs replication) in an additive model. Logistic regressions for the association of blood groups compare the relevant blood group (eg, O, A, B, or AB) to all other blood groups combined. Sensitivity analyses included functional assay-positive cases compared with PF4/heparin antibody-positive controls alone (excluding antibody-negative controls) and functional assay-positive cases compared with PF4/heparin antibody-negative controls alone (excluding antibody-positive controls) and after adjustment for PF4/heparin antibody IgG levels.