Figure 1.
Recombinant fibrinogen variants γDEK, γD297N, γE323Q, and γK356Q corresponding to extended knob-hole interactions affect fibrin polymerization. (A) Polymerization curves, (B) lag phase duration, (C) polymerization rate Vmax, and (D) maximum optical density, MaxOD for all variants and WT fibrinogens. Mean ± standard deviation (SD), N = 3 (γDEK), N = 4 (single variants). **P < .01; ***P < .001, ****P < .0001 compared with WT.

Recombinant fibrinogen variants γDEK, γD297N, γE323Q, and γK356Q corresponding to extended knob-hole interactions affect fibrin polymerization. (A) Polymerization curves, (B) lag phase duration, (C) polymerization rate Vmax, and (D) maximum optical density, MaxOD for all variants and WT fibrinogens. Mean ± standard deviation (SD), N = 3 (γDEK), N = 4 (single variants). **P < .01; ***P < .001, ****P < .0001 compared with WT.

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