IFNγ coordinately regulates transcription of multiple pathways to promote both NAM-dependent and -independent NAD salvage. (A) Diagram of pathways by which IFNγ regulates cellular NAD⁺ metabolism. IFNγ activates STAT1, inducing CD38, NAMPT, and P2RX7 and inhibiting PDK4 and NRK2. (B) Heat map generated from RNA-Seq analysis of human monocyte–derived macrophages stimulated with IFNγ for 24 hours displaying genes involved in NAD(H) salvage. ND, normal donor.