Study flowchart and estimated risk of CNS relapse in transformed WM. (A) Flowchart of inclusion. Patients with transformed WM (254) were analyzed, 235 for CNS involvement at HT and 187 for CNS relapse. (B) Cumulative incidence of CNS relapses. (C) Cumulative incidence of CNS relapse stratified by kidney/adrenal involvement. (D) Cumulative incidence of CNS relapse stratified by the presence of MYD88^L265P mutation.