Integrative multi-omics analysis of hematopoietic stem and progenitor cell subpopulations in patients with PV. (A) Study outline. Protein image taken from reference ⁶⁹ . (B) Mutational analysis based on RNA-seq data in patients with PV showing specific point mutations (rows) identified in the various cell subpopulations of the PV patients tested (columns). Point mutations predicted by functional analysis through hidden Markov models as pathogenic are labeled in black, mutations classified as neutral are labeled in violet, and unclassified mutations are labeled in gray.³⁶  See also supplemental Figure 4. For PV1/8/12, samples from different individuals had to be pooled to guarantee adequate HSC/MPP numbers for downstream MS and RNA-seq measurements.