Figure 2.
Expression of CCR8 and ligands in CTCL skin and correlation with prognosis. (A) Heatmap of the unsupervised hierarchical clustering of 157 CTCL patients according to the Nanostring gene expression of 78 genes in lesional skin. Arrows indicate CCR8 and CCL18 gene expression. (B) Kaplan-Meier PFS curves of 157 CTCL patients according to their gene expression cluster. (C) Kaplan-Meier PFS curves of 157 CTCL patients according to CCR8 expression in lesional skin. (D) Kaplan-Meier PFS curves of 157 CTCL patients according to CCL18 expression in lesional skin. (E) Single-cell RNA sequencing data representing expression patterns of CCR8 ligands. Red dots show the localization of CCL1, CCL16, CCL8, and CCL18 among cell populations in the skin of CTCL patients.

Expression of CCR8 and ligands in CTCL skin and correlation with prognosis. (A) Heatmap of the unsupervised hierarchical clustering of 157 CTCL patients according to the Nanostring gene expression of 78 genes in lesional skin. Arrows indicate CCR8 and CCL18 gene expression. (B) Kaplan-Meier PFS curves of 157 CTCL patients according to their gene expression cluster. (C) Kaplan-Meier PFS curves of 157 CTCL patients according to CCR8 expression in lesional skin. (D) Kaplan-Meier PFS curves of 157 CTCL patients according to CCL18 expression in lesional skin. (E) Single-cell RNA sequencing data representing expression patterns of CCR8 ligands. Red dots show the localization of CCL1, CCL16, CCL8, and CCL18 among cell populations in the skin of CTCL patients.

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