Mass spectrometry of proteins present in EVs released by IVPCs and HMCLs. (A) Graph showing the average number of peptides mapped to each protein upregulated in HMCL EVs relative to IVPCs. (B) Graph showing the average number of peptides mapped to each protein downregulated in HMCL EVs relative to IVPCs. Mass spectrometry analysis of EVs was done using independently harvested triplicates for each HMCL and IVPC generated from individual blood donors. Means ± standard deviation (SD) are shown. *P ≤ .01; others are P < .05.