Distribution of de novo LASP LC50 values in primary ALL cells and descriptive genomic features. (A) Frequency distribution of de novo LASP LC50 values in patients (n = 212). (B) Subtype specific differences in LASP LC50 (n = 212). The mean LC50 for each subtype is depicted as a red bar. Green shading represents the concentration range associated with drug sensitivity, while red shading represents the concertation range associated with drug resistance. (C) Frequency of MRD+ patients at day 15 or 42 of therapy. Green (in A) or blue (in B) bars represent patients found to be LASP sensitive, while red shading represents patients found to be intermediate or resistant to LASP. Comparisons between positivity rate and LASP sensitivity class for each time point were performed with Fisher’s Exact test (P < .05).