Sex-specific pattern of DDX3X mutations in hBL is not replicated in cBCL. (A) Spatial distribution of mutations observed in DDX3X, compared with hBL. (B) Spatial distribution of DDX3X mutations in male and female cases of hBL. The odds ratio corresponding to the presence of truncating mutations in male cases of BL is infinite (95% confidence interval [CI], 1.44-Inf; P = .00918). (C) Spatial distribution of DDX3X mutations in canine male and female cBCLs. (D) Protein percentage identity, calculated by Clustal Ω, is highly similar between human and canine DDX3X and the Y-linked paralog DDX3Y. (E) Expression of DDX3Y mRNA is significantly higher in male hBL when a mutation in DDX3X is present.