Predicted activation state of PEG-rIL-29–treated Lgr5⁺ and Lgr5^– sorted GI epithelial cells. Cytokines (A), transcriptional regulators (B), and kinases (C) with significantly associated transcriptional changes in sorted Lgr5⁺ and Lgr5^– intestinal epithelial cells after in vivo PEG-rIL-29-administration using Ingenuity pathway analysis. Bubble plot representation of significant enrichment scores (activation z score >2) in at least one treatment condition (ie, PEG-rIL-29). Color indicates predicted activation (red) or predicted inhibition (green), and bubble diameter represents the −log₁₀P value as determined by Fisher’s exact test. Crosses signify a lack of significant activation scores at specific time points.