Glycan diversity. Schematic figures of glycans and genes that regulate platelet production and clearance. (A) N-glycans are bound to glycoproteins through an N-glycosidic bond to asparagine (Asn). Depending on how their core is branched out, they can be classified as oligomannose, complex, or hybrid. (B) O-glycans are bound through an O-glycosidic bond to serine (Ser) or threonine (Thr). (C) Proteoglycans consist of a protein core (orange) and ≥1 covalently attached GAG chains. GAGs consist of repeating disaccharide units composed of an N-acetylated or N-sulfated hexosamine and either a uronic acid (GlcA or IdoA) or galactose. LacNAc, N-acetyllactosamine; TF, Thomsen-Friedenreich.