Figure 1.
Contact and intrinsic pathway activation in patients and healthy individuals. Dot plots showing plasma levels of intact high molecular weight HK (A), cleaved HK (B), kallikrein:C1 inhibitor (C), FXIIa:C1 (D), FXIa:C1 inhibitor (E), FXIa:α1-antitrypsin (F), FXIa:antithrombin (G), and FIXa:AT (H). Mean ± standard deviation or median (horizontal bars) depicted for Gaussian and non-Gaussian data, respectively; similarly, P values are from t or Mann-Whitney test according to data distribution (n = 28-30 per group). Notably, because the standard curve typically spans 4 logs for FXIa:α1-antitrypsin complex, many patient samples exceeded the upper limit of detection. Samples from 2 patients were not processed because of critical preanalytic issues (low volume).

Contact and intrinsic pathway activation in patients and healthy individuals. Dot plots showing plasma levels of intact high molecular weight HK (A), cleaved HK (B), kallikrein:C1 inhibitor (C), FXIIa:C1 (D), FXIa:C1 inhibitor (E), FXIa:α1-antitrypsin (F), FXIa:antithrombin (G), and FIXa:AT (H). Mean ± standard deviation or median (horizontal bars) depicted for Gaussian and non-Gaussian data, respectively; similarly, P values are from t or Mann-Whitney test according to data distribution (n = 28-30 per group). Notably, because the standard curve typically spans 4 logs for FXIa:α1-antitrypsin complex, many patient samples exceeded the upper limit of detection. Samples from 2 patients were not processed because of critical preanalytic issues (low volume).

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