Identification of a spatial pattern of ICH. (A) Representative images of E10.5 to E17.5 heads and brains 48 hours after treatment with anti-GP1Bα or IgG (scale bars, 1 mm). (B) Frequency of hemorrhage in the ganglionic eminence (GE) and the cortex of treated E10.5 to E17.5 mice after 48 hours (E10.5: IgG n = 16, GP1Bα n = 8; E12.5: IgG n = 12, GP1Bα n = 17; E14.5: IgG n = 17, GP1Bα n = 16; E16.5: IgG n = 18, GP1Bα n = 14; E17.5: IgG n = 17, GP1Bα n = 14). Total number of mice with ICH is provided in parentheses. (C) Frequency of hemorrhage in the GE and the cortex of treated E10.5 to E17.5 mice after 6 hours (E10.5: IgG n = 8, GP1Bα n = 8; E12.5: IgG n = 9, GP1Bα n = 8; E14.5: IgG n = 7, GP1Bα n = 8; E16.5: IgG n = 7, GP1Bα n = 14; E17.5: IgG n = 6, GP1Bα n = 11). Total number of mice with ICH is provided in parentheses. (D) Representative images of hemorrhage in E14.5 (IgG n = 6, GP1Bα n = 7) and E17.5 (IgG n = 4, GP1Bα n = 6) embryos 6 hours posttreatment (scale bars, 1 mm). Yellow arrows indicate sites of hemorrhage.