A proposed mechanism for the increased antileukemia activity of Duv-CART cells. T-cell receptor signaling activates PI3K phosphorylation through phosphorylation of protein lipase C (not shown). Duvelisib inhibits the active sites of PI3Kδ and PI3Kγ at the p110δ and p110γ subunits. Processes that duvelisib upregulates are shown in green, and processes that duvelisib downregulates are shown in red.