American Society of Hematology

Figure 2.

Inhibitors of platelet ADP and thromboxane A2 signaling provide limited protection against VT. WT mice were treated with aspirin and/or clopidogrel to inhibit Cox1 and P2Y12, respectively, and subjected to FeCl3-induced carotid artery thrombosis or to IVC stenosis for 48 hours. (A) Flow cytometric analysis of integrin activation response (JON/A-PE binding) to ADP in blood from mice treated with low (LDAPT) or high (HDAPT) doses of DAPT. (B) Vessel occlusion times after FeCl3 treatment for 3 minutes; the experiment was terminated at 30 minutes. NO indicates no occlusion. (C) Thrombus weights after 48 hours of IVC flow restriction. Dots represent individual mice, bars indicate medians. ∧P < .07; *P < .05; **P < .01; ****P < .0001. MFI, mean fluorescence intensity.

Inhibitors of platelet ADP and thromboxane A₂ signaling provide limited protection against VT. WT mice were treated with aspirin and/or clopidogrel to inhibit Cox1 and P2Y₁₂, respectively, and subjected to FeCl₃-induced carotid artery thrombosis or to IVC stenosis for 48 hours. (A) Flow cytometric analysis of integrin activation response (JON/A-PE binding) to ADP in blood from mice treated with low (^LDAPT) or high (^HDAPT) doses of DAPT. (B) Vessel occlusion times after FeCl₃ treatment for 3 minutes; the experiment was terminated at 30 minutes. NO indicates no occlusion. (C) Thrombus weights after 48 hours of IVC flow restriction. Dots represent individual mice, bars indicate medians. ^∧P < .07; *P < .05; **P < .01; ****P < .0001. MFI, mean fluorescence intensity.

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