Thrombocytopenia protects mice from VT. WT mice were treated with anti-GPIbα (platelet-depleting) antibody. (A) Thrombus weight after 48 hours of IVC flow restriction. (B) Flow cytometric analysis of the peripheral platelet count before (Pre) and after (Post) anti-GPIbα treatment. Only mice with peripheral platelet counts ≤1% of control mice were subjected to the stenosis model. Dots represent individual mice, bars indicate medians. ***P < .001; ****P < .0001.