GPVI activation requires receptor clustering but not dimerization. On resting platelets, GPVI monomers (shown in blue) are present on the platelet surface co-expressed with the FcRγ chain (red). A limited proportion of GPVI is present as dimers. GPVI clustering along a collagen fiber increases the local concentration of the FcRγ chain resulting in amplified signaling events leading to platelet activation. The role of dimerization is to further increase the concentration of FcRγ. The yellow star represents an interaction with collagen and highlights that only 1 GPVI within a dimer can interact with collagen. Professional illustration by Patrick Lane, ScEYEnce Studios.