Summary of metabolic and protein changes in central carbon metabolism in primitive BasoEs at E10.5 vs primitive OrthoEs at E12.5 of mouse gestation. Proteins are indicated by rectangles, and metabolites are indicated by circles. The filled color of each is proportional to the log₂(fold change) at E12.5 with respect to E10.5 level, where blue to red represents a log₂(fold change) of −5 to 5, respectively. Gene symbols are provided for each protein. ALDO, aldolase; BPGM, bisphosphoglycerate mutase; ENO, enolase; FH, fumarate hydratase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSH, reduced glutathione; GSSG, oxidized glutathione; LDHA, lactate dehydrogenase-A; OGDH, oxoglutarate dehydrogenase; PFKL, phosphofructokinase, liver type; PGD, phosphogluconate dehydrogenase; RPE, ribulose-phosphate 3-epimerase; RPIA, ribose-5-phosphate isomerase A; SDH, succinate dehydrogenase; TALDO, transaldolase; TKT, transketolase.