Kinetics of JAK2V617F allele burden of patients treated in the MPD-RC 112 trial. (A) Maximum change in JAK2V617F allele burden from baseline by response status. (B) JAK2V617F allele burden over time (*P < .05). Baseline (n = 117), 12-month (n = 97), and 24-month (n = 52) allele burden values were included in the mixed model.