![HSCT-treated GC/JAK3 patients have a generalized defect in nasopharyngeal type 2 immunity. (A) Nasopharyngeal levels of type 1 cytokines (interferon [IFN]-γ and tumor necrosis factor [TNF]-α). (B) Nasopharyngeal levels of type 2 cytokines (IL-4, IL-5, and IL-13). (C) Nasopharyngeal levels of type 3 cytokines (IL-17A, IL-17F, and IL-22). (D) Nasopharyngeal levels of IL-33, IL-6, and eosinophil cationic protein (ECP)/RNase 3. (E) Heatmap representation of the mean of the concentration of all nasopharyngeal cytokines in healthy and HSCT-treated SCID patients. Panels A-D: box plots with median ± minimum to maximum. P values were determined with the Kruskal-Wallis test followed by Dunn’s posttest for multiple group comparisons; *P < .05, **P < .005, ***P < .001. n.s., not significant.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/139/17/10.1182_blood.2021014654/4/bloodbld2021014654f2.png?Expires=1725180081&Signature=nfdU~fWsK6MwI-a~4MuiLvEyrl2LBpld9mweDARnfbCUq7z0DWq1RvLvPqIsl0ma8mRSH6uXwimPoUhDOx85YFA1WljXUw-lQLx29k4AlRj~4Ty6yfvdVZ~NyHBwCLF6d4b5Cej6SDQivLiem2tEkux1Z825~SN4NHU5e2XWKatJeV5K7sZSvOblIhLMiBfEPLVSpv5Q8bLxCY0tp3iDqPnssUSo0lFk6-fnjHSpUbGq9qWF-anYWSoSx5RBaF8JyP4RCTiNyNLWkyVPAO--k2S1lJAQU-1s-RqYVVOxkHKoY7a~XtI4VkH023bf-hEUZQketT~YY580yv4YAh2rOQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HSCT-treated GC/JAK3 patients have a generalized defect in nasopharyngeal type 2 immunity. (A) Nasopharyngeal levels of type 1 cytokines (interferon [IFN]-γ and tumor necrosis factor [TNF]-α). (B) Nasopharyngeal levels of type 2 cytokines (IL-4, IL-5, and IL-13). (C) Nasopharyngeal levels of type 3 cytokines (IL-17A, IL-17F, and IL-22). (D) Nasopharyngeal levels of IL-33, IL-6, and eosinophil cationic protein (ECP)/RNase 3. (E) Heatmap representation of the mean of the concentration of all nasopharyngeal cytokines in healthy and HSCT-treated SCID patients. Panels A-D: box plots with median ± minimum to maximum. P values were determined with the Kruskal-Wallis test followed by Dunn’s posttest for multiple group comparisons; *P < .05, **P < .005, ***P < .001. n.s., not significant.