Treatment effects on patient recorded outcomes. Absolute change from baseline over time with standard deviations are shown for eDiary outcomes during the blinded treatment period for study participants receiving canakinumab (red line) or placebo (blue line) using Bayesian models for average daily pain (A), average daily fatigue (B), and mean change from baseline ± SE for average daily absence from school or work (C). Dotted horizontal line references baseline levels.