HBsAg⁺ FLs display a distinct gene expression pattern. (A) HBsAg⁺ FLs showed a distinct gene expression profile. The normalized expression levels were analyzed using Qlucore Omics Explorer software. Significantly and differentially expressed genes between HBsAg⁺ (n = 24) and HBsAg⁻ (n = 77) FLs were used to draw the heatmap. (B) Comparison of expression signatures in HBsAg⁺ and HBsAg⁻ FLs. The expression signatures were determined using gene sets (https://lymphochip.nih.gov/signaturedb/) based on previously described methods.⁶⁶  (C-E) HBsAg⁺ FLs expressed higher levels of genes associated with ABC-DLBCLs (C) and lower levels of genes associated with GCB-DLBCLs (D), giving rise to an ABC-like phenotype in general (E). The analysis of ABC and GCB scores was performed based on previously described methods.⁴⁰  The Mann-Whitney U test was used to calculate the P value.