Figure 1.
Enhanced mutagenesis and enrichment of selected mutational signatures in HBsAg+ FLs. (A-B) Comparison of the mutation load in the whole genome (A) or coding genome (B) between HBsAg+ and HBsAg− FLs. (C) Mutational signatures were identified according to the 96-substitution classifications from 61 pairs of FL/control samples sequenced by WGS. (D-E) Comparison of Sig.F4 and Sig.F2 in HBsAg+ and HBsAg− FLs. (F) Two mutational signatures (Sig.FL-K1 and Sig.FL-K2) of kataegis were identified in FL genomes. (G) Comparison of the contribution of Sig.FL-K1 to kataegis identified in HBsAg+ and HBsAg− FLs. The numbers in brackets in panel C and panel F represent the cosine similarities between current signatures and indicated signatures. The Mann-Whitney U test was used to calculate the P value. ROS, reactive oxygen species; sig., signature.

Enhanced mutagenesis and enrichment of selected mutational signatures in HBsAg+ FLs. (A-B) Comparison of the mutation load in the whole genome (A) or coding genome (B) between HBsAg+ and HBsAg− FLs. (C) Mutational signatures were identified according to the 96-substitution classifications from 61 pairs of FL/control samples sequenced by WGS. (D-E) Comparison of Sig.F4 and Sig.F2 in HBsAg+ and HBsAg− FLs. (F) Two mutational signatures (Sig.FL-K1 and Sig.FL-K2) of kataegis were identified in FL genomes. (G) Comparison of the contribution of Sig.FL-K1 to kataegis identified in HBsAg+ and HBsAg− FLs. The numbers in brackets in panel C and panel F represent the cosine similarities between current signatures and indicated signatures. The Mann-Whitney U test was used to calculate the P value. ROS, reactive oxygen species; sig., signature.

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