Results from a Delphi-method survey conducted with lymphoma trial experts to modernize enrollment criteria for first-line DLBCL RCTs comparing R-CHOP vs R-CHOP plus targeted therapy. Round 1 (A) included 31 total criterion categories common to first-line DLBCL RCTs spanning the R-CHOP era. Criteria with median Likert-style values ≥7 were deemed essential. Criteria with median values ≤3 were deemed unnecessary. Criteria with median values >3 and <7 were either unresolved or showed disagreement based on response distribution and were revisited in round 2 (B). CD20, cluster of differentiation 20; CNS, central nervous system; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; IPI, international prognostic index; WBC, white blood cell.