Transcriptomic analysis implicates genes associated with endoplasmic reticulum stress-induced apoptosis. (A) BN-PAGE of purified mitochondrial from three WT ER-Hoxb8 clones and three TAFAZZIN-KO clones. The gel is Coomassie stained. The 5 mitochondrial supercomplexes are highlighted on the right. (B) Following quantification of the mitochondrial supercomplexes, the relative contributions of each supercomplex within each clone depicted. (C) Heat map representation of gene expression from WT (n = 6) and TAFAZZIN-KO (n = 5) GMP clones. (D) TAFAZZIN is the most highly differentially expressed gene. (E) The count per million (CPM) are displayed for select genes involved in mediated ER stress and apoptosis. The false discovery rate (FDR) is displayed with each gene.