The difference in mean ΔT at the lumbar spine (L1-L4) between patients in the efficacy group (n = 47) allocated to ALN and placebo groups. The displayed 95% confidence intervals indicate whether ALN has a significant effect in each subgroup. Test for differential effect of ALN between clinical subgroups did not reveal any significant differences: female vs male (P = .145), age <60 years vs age ≥60 years (P = .913), bone marrow involvement vs no involvement (P = .995), BMI <25 vs BMI ≥25 (P = .655), and R-CHOP vs other chemotherapy (P = .572).